# Kisspeptin papers, by question

> Kisspeptin reading list | Keystone Peptides — The Keystone Peptides reading list: original KISS1 and puberty discoveries, hormonal timing experiments, IVF research and brain studies.

**Reading list**

The puberty genetics and the fading hormonal responses make a particularly revealing pair.

## Discovery and pubertal development

[Lee and colleagues' KISS1 discovery](https://pubmed.ncbi.nlm.nih.gov/8944003/) opens in melanoma research. The [GPR54 study by Seminara and colleagues](https://pubmed.ncbi.nlm.nih.gov/14573733/) and [the family study by de Roux and colleagues](https://pubmed.ncbi.nlm.nih.gov/12944565/) move the story into puberty. [Teles and colleagues](https://pubmed.ncbi.nlm.nih.gov/18272894/) examine prolonged receptor responsiveness and early puberty; [Topaloglu and colleagues](https://pubmed.ncbi.nlm.nih.gov/22335740/) investigate an inactivating mutation in KISS1 itself. [Messager and colleagues](https://pubmed.ncbi.nlm.nih.gov/15665093/) connect the receptor to GnRH release in animal work.

## Hormonal responses over time

[George and colleagues' study in healthy men](https://pubmed.ncbi.nlm.nih.gov/21632807/) follows LH and its pulse frequency. The [hypothalamic-amenorrhea infusion study](https://pubmed.ncbi.nlm.nih.gov/24517142/) concerns restoration of LH pulses. The [repeated-administration experiment](https://pubmed.ncbi.nlm.nih.gov/19820030/) deserves to sit alongside it: the response faded. [Millar and Babwah's receptor review](https://pubmed.ncbi.nlm.nih.gov/25765628/) supplies the pharmacological context.

## Fertility and sexual processing

[Abbara and colleagues' IVF trial](https://pubmed.ncbi.nlm.nih.gov/26192876/) studies egg maturation in women at high OHSS risk. [The attraction-cue imaging study](https://pubmed.ncbi.nlm.nih.gov/32051344/) and [the trial in men with hypoactive sexual desire disorder](https://pubmed.ncbi.nlm.nih.gov/36735255/) pursue different questions about sexual processing and experience.

## Null findings and clinical status

I give the [anxiety trial](https://pubmed.ncbi.nlm.nih.gov/40036336/) and [the food-intake experiment in women with overweight or obesity](https://pubmed.ncbi.nlm.nih.gov/37039248/) a place alongside the positive findings. The [systematic review of clinical status](https://pubmed.ncbi.nlm.nih.gov/38265397/) surveys the interventional literature with a database search through February 2023; it was published in 2025.

## References

[1] KiSS-1, a novel human malignant melanoma metastasis-suppressor gene https://pubmed.ncbi.nlm.nih.gov/8944003/
[2] The GPR54 gene as a regulator of puberty https://pubmed.ncbi.nlm.nih.gov/14573733/
[3] Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 https://pubmed.ncbi.nlm.nih.gov/12944565/
[4] A GPR54-activating mutation in a patient with central precocious puberty https://pubmed.ncbi.nlm.nih.gov/18272894/
[5] Inactivating KISS1 mutation and hypogonadotropic hypogonadism https://pubmed.ncbi.nlm.nih.gov/22335740/
[6] Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 https://pubmed.ncbi.nlm.nih.gov/15665093/
[7] Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men https://pubmed.ncbi.nlm.nih.gov/21632807/
[8] Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54 https://pubmed.ncbi.nlm.nih.gov/24517142/
[9] Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis https://pubmed.ncbi.nlm.nih.gov/19820030/
[10] KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis https://pubmed.ncbi.nlm.nih.gov/25765628/
[11] Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy https://pubmed.ncbi.nlm.nih.gov/26192876/
[12] Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial https://pubmed.ncbi.nlm.nih.gov/36735255/
[13] Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men https://pubmed.ncbi.nlm.nih.gov/32051344/
[14] Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans https://pubmed.ncbi.nlm.nih.gov/40036336/
[15] The effects of kisspeptin on food intake in women with overweight or obesity https://pubmed.ncbi.nlm.nih.gov/37039248/
[16] Kisspeptin and its current clinical status - a systematic review https://pubmed.ncbi.nlm.nih.gov/38265397/

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Keystone Peptides follows my fascination with kisspeptin in published research, an editorial interest with no medical business behind its name and no medical advice in its pages.