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Keystone Peptides

A small signal, closely followed

Reading list

Kisspeptin papers, by question

The puberty genetics and the fading hormonal responses make a particularly revealing pair.

Discovery and pubertal development

Lee and colleagues' KISS1 discovery opens in melanoma research. The GPR54 study by Seminara and colleagues and the family study by de Roux and colleagues move the story into puberty. Teles and colleagues examine prolonged receptor responsiveness and early puberty; Topaloglu and colleagues investigate an inactivating mutation in KISS1 itself. Messager and colleagues connect the receptor to GnRH release in animal work.

Hormonal responses over time

George and colleagues' study in healthy men follows LH and its pulse frequency. The hypothalamic-amenorrhea infusion study concerns restoration of LH pulses. The repeated-administration experiment deserves to sit alongside it: the response faded. Millar and Babwah's receptor review supplies the pharmacological context.

Fertility and sexual processing

Abbara and colleagues' IVF trial studies egg maturation in women at high OHSS risk. The attraction-cue imaging study and the trial in men with hypoactive sexual desire disorder pursue different questions about sexual processing and experience.

Null findings and clinical status

I give the anxiety trial and the food-intake experiment in women with overweight or obesity a place alongside the positive findings. The systematic review of clinical status surveys the interventional literature with a database search through February 2023; it was published in 2025.

  1. KiSS-1, a novel human malignant melanoma metastasis-suppressor gene ↗
  2. The GPR54 gene as a regulator of puberty ↗
  3. Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 ↗
  4. A GPR54-activating mutation in a patient with central precocious puberty ↗
  5. Inactivating KISS1 mutation and hypogonadotropic hypogonadism ↗
  6. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54 ↗
  7. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men ↗
  8. Increasing LH pulsatility in women with hypothalamic amenorrhoea using intravenous infusion of kisspeptin-54 ↗
  9. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis ↗
  10. KISS1R: Hallmarks of an Effective Regulator of the Neuroendocrine Axis ↗
  11. Efficacy of kisspeptin-54 to trigger oocyte maturation in women at high risk of ovarian hyperstimulation syndrome (OHSS) during in vitro fertilization (IVF) therapy ↗
  12. Effects of kisspeptin on sexual brain processing and penile tumescence in men with hypoactive sexual desire disorder: a randomized clinical trial ↗
  13. Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men ↗
  14. Kisspeptin administration stimulates reproductive hormones but does not affect anxiety in humans ↗
  15. The effects of kisspeptin on food intake in women with overweight or obesity ↗
  16. Kisspeptin and its current clinical status - a systematic review ↗